HYALURONIC ACID: A KEY MOLECULE IN SKIN AGING
The key molecule involved in skin moisture is hyaluronic acid (HA) that has a unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association, and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multi-gene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.
- Mitigation of forehead lines and periorbital fine wrinkles.
- Improving lip shale and fullness as well as overall appearance of aging skin.
- Beneficial trends were noted in the appearance of coarse wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness.
