GnRH Therapy

Male hypogonadotropic hypogonadism (HH) is due to genetic or acquired factors from the hypothalamus, synthesis, transport, and pituitary secretion gonadotropin-releasing hormone (GnRH), or from gonadotropin disorders. 

Gonadorelin is responsible for the release of follicle-stimulating hormone and luteinizing hormone from the anterior pituitary. In the pituitary, GnRH stimulates the synthesis and release of FSH and LH. This process is controlled by the frequency and amplitude of GnRH pulses and the feedback of androgens and estrogens. 

GnRH therapy is most effective in the induction of spermatogenesis and pregnancies in hypogonadotropic hypogonadal men, despite maldescended testes, low initial testicular volumes or sperm concentrations below the normal limit.