Peptides of synthesis are a very new strategy in cosmetic science and technology for at least two reasons: (1) they are small molecules, easily penetrable in the skin, and (2) they are able to induce a very specific action because all skin cells (keratinocytes, fibroblasts, nervous cells) have membrane receptors for peptides. This group of cosmeceuticals includes the Botox-like peptides, represented by acetyl hexapeptide 3 (Argireline) and pentapeptide-3 (Leuphasyl). There is a synergistic effect of Leuphasyl and Argireline when taken together.
GHK as a signal peptide enhances collagen production and acting as a carrier peptide when complexed with Cu(II). Stimulates collagen and glycosaminoglycan synthesis in skin fibroblasts. Reverse gene expression to a healthier state. Reparative and anti-aging properties.
Pentapeptide-18 composed of the sequence H-Tyr-Ala-Gly-Phe-Leu-OH Was first reported in 2015. It became one of the most popular active ingredients in anti-aging formulations. Studies acknowledge its effectiveness in wrinkle reduction.
Argireline is a synthetic peptide that is patterned from the N-terminal end of the protein SNAP-25 and has been shown to reduce the degree of facial wrinkles.
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